TEAM

 

JEFF KARP

Photo of Professor Jeffrey M Karp
Professor Jeffrey M Karp
Principal Investigator

Dr. Jeff Karp is a Professor of Medicine at Brigham and Women’s Hospital, Harvard Medical School, Principal Faculty at the Harvard Stem Cell Institute, and an affiliate faculty at the Broad Institute and at the Harvard-MIT Division of Health Sciences and Technology (where he teaches to HST and MIT-Sloan business school students). His work spans the fields of drug delivery, medical devices, stem cell therapeutics, and tissue adhesives. He He has published >100 peer-reviewed papers (with >14,000 citations), has given >250 national and international invited lectures, and has >100 issued or pending national/international patents. Several technologies developed in his lab have formed the foundation for multiple products on the market and currently under development and for the launch of six companies that have raised over $100 Million in funding including Skintifique (a skincare company), Gecko Biomedical (a tissue adhesive company), Alivio Therapeutics (an inflammation targeting company), Frequency Therapeutics (a regenerative medicine company), Molecular Infusions (a cannabinoid company), and Landsdowne Labs (a child safety company). In 2014, Skintifique brought four consumer healthcare products to market that are sold in pharmacies throughout Europe and are globally available. In 2017, Gecko Biomedical received European regulatory approval (CE mark) for its first tissue sealant product and was recognized by Fierce Medtech as part of their Fierce 15 list of 2017. Frequency Therapeutics began human clinical testing in 2017 for its lead program to treat chronic hearing loss and just completed a successful Phase I safety study in Australia.

Karp’s laboratory has been funded by multiple companies, foundations, and governmental funding agencies, including the Bill and Melinda Gates Foundation, NFL, Johnson & Johnson, Phillips, Sanofi, UCB, NIH, DOD, US Army, Kenneth Rainin Foundation, Helmsley Trust, JDRF, Rheumatology Research Foundation, Coulter Foundation, Prostate Cancer Foundation, Brain Science Foundation, American Heart Association, Deshpande Foundation, Institute for Pediatric Innovation, Boston Children’s Hospital, Brigham and Women’s Hospital, the Government of India and the Government of Korea. Karp also won an internal Shark Tank award judged by Kevin O’Leary (from ABC’s Shark Tank).

Karp’s work has been published in several high impact journals, including six papers in the Proceedings of the National Academy of Sciences (including two cover features), four in Nature Nanotechnology (including a cover feature), three in Cell Stem Cell, one in Nature Biotechnology, one in Nature Methods, one in Nature Biomedical Engineering, one in Nature Protocols, four in Science Translational Medicine (including two cover features), one in Nature Communications, and two in Blood. Karp also has published a commentary in Nature and another in the New England Journal of Medicine.

Karp’s work has been discussed in hundreds of newspapers, online websites, television newscasts, and radio shows around the world, including CNN, ABC News, NBC, Boston Globe, Los Angeles Times, BBC, Discovery, National Geographic, The Atlantic, The Guardian, American Museum for Natural History, Popular Mechanics, and CTV Canada AM, among many others. Karp has also appeared multiple times on CBC’s Quirks and Quarks and NPR Science Fridays. Karp has given invited lectures in 14 countries outside of the US including Canada, Israel, Ireland, United Kingdom, Denmark, Japan, Korea, Italy, India, Colombia, France, Chile, Switzerland, and Germany.

Karp has received over 50 awards and honors. Boston Magazine recently recognized Karp as one of 11 Boston Doctors Making Medical Breakthroughs. The Boston Business Journal recognized him as a Champion in Healthcare Innovation and MIT’s Technology Review Magazine (TR35) also recognized Karp as being one of the top innovators in the world (three members from his laboratory have subsequently received this award). Karp is also a Kavli Fellow and was elected to the American Institute for Medical and Biological Engineering’s College of Fellows in 2013. His work has been selected by Popular Mechanic’s as one of the Top 20 New Biotech Breakthroughs that Will Change Medicine. He gave a TEDMED talk at the Kennedy Center in DC on bioinspired medical innovation, and since 2015 has been a member of the TEDMED Editorial Advisory Board. In 2015 and 2016, he received Breakthrough Awards from the Kenneth Rainin Foundation, and in 2015 was a commencement speaker in at the University of Toronto Faculty of Dentistry and Pharmacy. He also has served as a consultant to the Kenneth Rainin Foundation and the Crohn’s and Colitis Foundation on the topic of new technologies for Inflammatory Bowel Disease. He has deep consulting expertise with startups and Fortune 500 companies across a wide spectrum of areas, including drug delivery, medical devices, consumer healthcare products, and stem cell therapeutics.

Karp has had several notable scholarly achievements during his career. In 2010, Karp was asked to serve a two-year term to co-lead the Brigham and Women’s Hospital Regenerative Therapeutics Center (making him the youngest faculty at the Brigham and Women’s Hospital to direct a research center). He also received the Society for Biomaterials Young Investigator Award and the Coulter Foundation Translational Young Investigator Award. Additionally, he was a visiting professor at Oxford in 2014, presented the Nicholson Memorial Lecture at Composites of Lake Louise in 2015, presented two public lectures at the American Museum of Natural History in 2016, gave a Keynote Lecture at the Ontario Hospital Association’s 2017 Health Achieve conference, was a Plenary Speaker at the Tissue Engineering Society Europe conference in 2017, and was a Keynote speaker in 2018 at the combined meeting of the American Society for Peripheral Nerve, American Society for Reconstructive Microsurgery, and the American Association for Hand Surgery.

In addition to his research goals, Karp is dedicated to the career development of next generation bioengineers to work at the forefront of regenerative medicine. Karp was selected as the Outstanding Faculty Undergraduate Mentor among all faculty at MIT and he received the HST McMahon Mentoring award for being the top mentor of Harvard-MIT students. Karp strives to create an educationally conducive environment that fosters the development of scientific confidence. To date, 20 trainees from his laboratory have secured faculty positions (he currently has 4 faculty working in his lab who he promoted from postdoctoral positions) and several have transitioned into impactful careers in pharma, biotech, medtech, and venture capital. Karp dedicates significant time to inspiring the next generation through hosting multiple groups of grade school and high school children to his laboratory each year for lectures and hands on demonstrations (including those from the US, Japan, Sweden, and France), as well as through giving lectures at local and national schools, including schools in Massachusetts, Connecticut, Oregon, and Washington. For example, in 2017 he gave a lecture at the Talcott Mountain Academy in Avon CT (a school for gifted children). He also has been a speaker at the Global Youth Summit at Brandeis University for the past two years. Karp has also collaborated extensively with clinicians, basic scientists, engineers, and fellow bioengineers in the US and in India, where he co-directed an Indo-US Center for Nanobiotechnology, and was invited to help launch a new biomedical engineering program at the Pontifical Catholic University of Chile.

 

LAB MANAGER

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Laura Badia

I am the Lab Manager at the Karp Lab; I joined in February of 2014. I handle the administrative side of the lab as well as grants and lab safety. I received my BS in Biology with a minor in Child Development and Family Relations and I am currently working on my MSM in Healthcare Administration. I have been part of Brigham and Women’s Hospital for the past three years and prior to joining the lab, I worked directly in the hospital and its corporate office.

In addition to fulfilling one of my passions, which is facilitating research, I love spending time with my family and friends, staying active, the outdoors, the beach, traveling, my sorority Lambda Theta Alpha, food and ice cream, shopping, reading and the color pink.

INSTRUCTORS

Photo of Nitin Joshi Ph.D.
Nitin Joshi Ph.D.
Hi! My current research  involves the development of next generation biomaterials for drug delivery. I received PhD in 2013 from the Indian Institute of Technology, Bombay, India, where I studied under the supervision of Prof. Rinti Banerjee. My work was focused on the development of stimuli-responsive nanoparticles for the delivery of single and combinatorial anti-cancer drugs, both systemically as well as through non-invasive routes. My postdoc work with Prof. Jeffrey Karp at Brigaham and Women’s Hospital was focused on the development of inflammation-responsive hydrogel and nanoparticles for controlled drug delivery in multiple applications. Other than research, I am very passionate about music and have specific interests in Indian Classical Music (Khayal style).
Photo of Yuhan Lee Ph.D.
Yuhan Lee Ph.D.

My key focus is to identify the clinical and therapeutic unmet needs and to find solutions through biomaterials approach. I have been developing novel biomaterials for medical adhesive, drug delivery/formulation, and tissue engineering. My expertise in synthesis and characterization of new materials, coupled with my desire to solve important medical problems through a highly collaborative research is critical for the translational research which is my goal to take innovative approaches to the market to reach people.

Photo of Oren Levy Ph.D.
Oren Levy Ph.D.

I’m Oren Levy, an instructor in Prof. Karp’s lab. I received my B.Sc. in biology from Ben Gurion University (BGU), located in Beer Sheva, Israel. I carried out my M.Sc research in BGU, focusing on the JAKSTAT pathway and its involvement in vascular smooth muscle cell hypertrophy. During my PhD research, also performed in BGU, I studied the biochemistry and physiology of human mesenchymal stem cells (hMSCs). I investigated the roles of signal transduction pathways in hMSC physiological processes, specifically, the involvement of the JAK/STAT cascade in hMSC proliferation and osteogenic differentiation. My post doc research in the Karp lab focused on hMSC homing and engraftment to various sites in the body. I have enjoyed my work in the lab so far, and have had the privilege to engage in multiple collaborations with our great lab members. My hobbies include soccer, tennis and basketball. In addition, I’m a huge fan of F.C Hapoel BeerSheva (“Ani adom balev baneshama”).

Xiaolei Yin Ph.D.

STAFF

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CO-MENTORED PERSONNEL

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CLINICAL INTERNS

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POST-DOCTORATES

Eunjee (Ashley) Lee Ph.D.
Photo of Wen Li Ph.D.
Wen Li Ph.D.

I am a postdoctoral associate who is co-advised by Professor Langer (The Koch Institute  for Integrative Cancer Research, MIT) and Professor Karp (Brigham and Women’s Hospital, Harvard Medical School). I received the Ph.D. Degree from Changchun institute of applied chemistry, Chinese Academy of Sciences in 2016. My research interests focus on the exploitation of stimuli-responsive materials, the controlled drug delivery, as well as stem-cell based therapy. Other than research, I enjoy traveling.

Photo of Yue Shao Ph.D.
Yue Shao Ph.D.

I joined the Karp lab as a postdoctoral associate in the summer of 2017, after I graduated from the University of Michigan, Ann Arbor, with a doctoral degree in Mechanical Engineering. My doctoral research includes the mechanics and mechanobiology of cells as well as the application of human pluripotent stem cells for modeling early human embryogenesis in vitro. My postdoctoral research joining the forces of the Karp lab and the Langer lab focuses on adult stem cells, biomedical devices, and regenerative medicine. Aside from lab work, I enjoy books, jigsaw puzzles, exercises and many outdoor activities.

Photo of Kisuk Yang Ph.D.
Kisuk Yang Ph.D.

I am a postdoctoral research fellow in Karp Lab. I majored in Biotechnology and earned Ph.D. degree at Yonsei University, Republic of Korea. I studied with interest on neural and bone tissue engineering using human stem cells under Professor Seung-Woo Cho. Recently I am interested in recapitulation of in vivo-like pancreatic islet niches for functional islet differentiation of human stem cells. Aside from lab work, I enjoy traveling, swimming, and watching baseball game.

GRADUATE STUDENTS

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Raquel Cunha

I am Raquel Cunha and I am currently pursuing a PhD in Bioengineering from MIT Portugal Program.  The goal of my PhD is to develop clinical grade stem cell-based therapies with enhanced regeneration potential. My project is being developed as collaboration between Karp’s lab and Wyss Institute, Boston, and Instituto Superior Técnico (IST) from University of Lisbon, Portugal. My background is an Integrated Master in Biological Engineering at IST, Portugal. As personal interests, I like hiking, volleyball and travelling.

Photo of Benjamin Elliott Mead
Benjamin Elliott Mead

Hello, I’m a graduate student in the Harvard-MIT Medical Engineering and Medical Physics PhD program. My research interests revolve around regenerative medicine, specifically in the application of novel stem cell technologies towards the development of translational therapies. I received my bachelors degree in Chemical & Biological Engineering from the University of Colorado Boulder and have previously worked with the Harvard Stem Cell Institute and National Institute of Standards and Technology. In addition to research, I enjoy any and all outdoor activities (hiking, cycling, skiing, etc..) as well as photography and traveling.

UNDERGRADUATES

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Connor Gallin

I am research assistant in the Karp Lab working on formulations for drug delivery. I joined the lab after graduating with a chemistry degree from  Northeastern University in May 2017. During my undergraduate studies I completed 3 co-ops at Celgene, Sanofi, and Amgen and conducted research with Professor Kirss examining the kinetics of phosphine and halide substitution in catalytically active ruthenium compounds.

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Zachary Hammond

I’m an undergraduate student studying Chemistry at Northeastern University. I work with Dr. Nitin Joshi developing hydrogel systems for drug delivery. Outside of the lab, I enjoy being outside preferably hiking or skiing.

Photo of Geonho (Tom) Park
Geonho (Tom) Park

I am an undergraduate student at KAIST majoring in Biomolecular and Chemical Engineering. I am currently working under Dr. Yuhan Lee, researching bioinspired adhesives for surgical applications. During my internship at the Karp Lab, I hope to explore and experience the vast field of biomedical engineering and translational nanomedicine. In my free time, I enjoy working out and watching NFL and NBA games.

Photo of Jane (Hijun) Seo
Jane (Hijun) Seo

Greetings! My name is Jane and I am an undergraduate student majoring in Biomedical Systems Engineering in the Engineering Science program at the University of Toronto. I am currently working as a part of Dr. Yuhan Lee’s team on projects involving bio-inspired adhesives for clinical applications. Outside of the lab, I enjoy sitting in a busy cafe while sipping a nice cold iced Americano, playing romantic period pieces and movie soundtracks on my cello, and singing karaoke despite my limited vocal range.

Photo of Daphne Sze
Daphne Sze

Hi! I am an undergraduate student studying Biomedical Systems Engineering at the University of Toronto. As a research trainee, I work with Benjamin Mead in the development of translational therapies through the application of intestinal stem cell technologies. Outside of the lab, I enjoy traveling, watching musicals and tasting new foods.

Photo of Yufeng Wang
Yufeng Wang

I am an undergraduate student at the University of Toronto majoring in Chemical Engineering. I am part of Dr. Joshi’s team for research and development of arthritis drug delivery system. During my internship at the Karp Lab, I hope to expand my knowledge in biomedical engineering and medicine in general. Outside of the lab, I enjoy hiking, working out and reading Buddhism literature

ALUMNI