TEAM

 

JEFF KARP

Photo of Professor Jeffrey M Karp
Professor Jeffrey M Karp
Principal Investigator

Dr. Jeff Karp is a world leader in drug delivery, stem cell therapeutics, and tissue adhesives. He is an Associate Professor at Brigham and Women’s Hospital, Harvard Medical School, Principal Faculty at the Harvard Stem Cell Institute, and an affiliate faculty at the Broad Institute and at the Harvard-MIT Division of Health Sciences and Technology.

He has published >100 peer-reviewed papers (>10,500 citations) and has given 220 national and international invited lectures and has 65 issued or pending patents. Several of his technologies have formed the foundation for products on the market or under development and for the launch of companies including: Gecko Biomedical, Skintifique, Frequency Therapeutics, and Alivio Therapeutics.

The Boston Business Journal recognized Dr. Karp as a Champion in Healthcare Innovation and MIT’s Technology Review Magazine (TR35) recognized him as being one of the top innovators in the world (3 members from his laboratory have received this award).

His work has been selected by Popular Mechanic’s “Top 20 New Biotech Breakthroughs that Will Change Medicine.” He gave a TEDMED talk on bioinspired medical innovation and is a member of the TEDMED Editorial Advisory Board. In 2015 he received a Breakthrough Award from the Kenneth Rainin Foundation and was a commencement speaker at the University of Toronto.

Dr. Karp was selected as the Outstanding Faculty Undergraduate Mentor among all Faculty at MIT and he received the HST McMahon Mentoring award for being the top mentor of Harvard-MIT students. To date, 18 trainees from his laboratory have secured faculty positions and many others impactful positions in pharma and biotech industries.

LAB MANAGER

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Laura Badia

I am the Lab Manager at the Karp Lab; I joined in February of 2014. I handle the administrative side of the lab as well as grants and lab safety. I received my BS in Biology with a minor in Child Development and Family Relations and I am currently working on my MSM in Healthcare Administration. I have been part of Brigham and Women’s Hospital for the past three years and prior to joining the lab, I worked directly in the hospital and its corporate office.

In addition to fulfilling one of my passions, which is facilitating research, I love spending time with my family and friends, staying active, the outdoors, the beach, traveling, my sorority Lambda Theta Alpha, food and ice cream, shopping, reading and the color pink.

INSTRUCTORS

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Oren Levy PhD

I’m Oren Levy, an instructor in Prof. Karp’s lab. I received my B.Sc. in biology from Ben Gurion University (BGU), located in Beer Sheva, Israel. I carried out my M.Sc research in BGU, focusing on the JAKSTAT pathway and its involvement in vascular smooth muscle cell hypertrophy. During my PhD research, also performed in BGU, I studied the biochemistry and physiology of human mesenchymal stem cells (hMSCs). I investigated the roles of signal transduction pathways in hMSC physiological processes, specifically, the involvement of the JAK/STAT cascade in hMSC proliferation and osteogenic differentiation. My post doc research in the Karp lab focused on hMSC homing and engraftment to various sites in the body. I have enjoyed my work in the lab so far, and have had the privilege to engage in multiple collaborations with our great lab members. My hobbies include soccer, tennis and basketball. In addition, I’m a huge fan of F.C Hapoel BeerSheva (“Ani adom balev baneshama”).

Xiaolei Yin PhD

STAFF

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Nicholas Sherman

My name is Nick Sherman and I am a research assistant here in the Karp Lab. I graduated from Northeastern University in 2015 with bachelors degrees in behavioral neuroscience and chemistry. I am currently working on several projects which aim to treat diseases like cancer, HIV and arthritis.

In my free time I enjoy volunteering as an EMT and reading. After Karp Lab I am looking forward to a career as a physician.

CO-MENTORED PERSONNEL

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CLINICAL INTERNS

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POST-DOCTORATES

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Nitin Joshi

Hi, I am a postdoctoral fellow in Karp Lab. My current research interests involve development of next generation biomaterials, including particles and hydrogels for drug delivery. I received a PhD in 2013 from the Indian Institute of Technology, Bombay, India, where I studied under the supervision of Prof. Rinti Banerjee. My work was focused on the development and evaluation of stimuli-responsive nanoparticles for the delivery of single and combinatorial anti-cancer drugs, both systemically as well as through non-invasive routes. Other than research, I am very passionate about music and have received formal training in Indian Classical Vocal Music (Khayal style).

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Yuhan Lee PhD

I’m a post-doctoral fellow in Karp Laboratory developing bio-adhesives for medical applications. I received my PhD in biological sciences in Korea Advanced Institute of Science and Technology (2010). While in KAIST, I studied under Professor Tae Gwan Park investigating biomaterials for wide variety of biomedical applications including drug/gene delivery and imaging for cancer therapy, injectable hydrogels for tissue regeneration, bio-inspired adhesive polymers for medical applications, carbon nanotube fiber fabrication, drug-eluting balloon catheter and stent for ischemic heart disease, and microneedle-based drug/gene delivery.

Photo of Aniruddh Solanki
Aniruddh Solanki

I am currently a Postdoctoral Research Fellow in the Karp Lab focusing on establishing platform technologies—to target primary and metastatic prostate cancer—that can be rapidly translated to the clinic. This primarily involves developing nanoparticle-based approaches to deliver drug-loaded particles to sites of cancer metastasis using cells of the immune system as vehicles. I completed my PhD in Chemistry and Chemical Biology at Rutgers University, where as a graduate student I was involved in designing and fabricating nanotechnology-based approaches for regenerating neurons and modulating the behavior of brain tumor cells.  I was also involved in designing biosensors to detect ultrasmall levels of breast cancer biomarkers. I like to travel, bike around Boston, and talking to people—about science and otherwise.

GRADUATE STUDENTS

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Raquel Cunha

I am Raquel Cunha and I am currently pursuing a PhD in Bioengineering from MIT Portugal Program.  The goal of my PhD is to develop clinical grade stem cell-based therapies with enhanced regeneration potential. My project is being developed as collaboration between Karp’s lab and Wyss Institute, Boston, and Instituto Superior Técnico (IST) from University of Lisbon, Portugal. My background is an Integrated Master in Biological Engineering at IST, Portugal. As personal interests, I like hiking, volleyball and travelling.

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Peter Anthony Jones

Peter Anthony Jones is a graduate student pursuing his PhD in Medical Engineering and Medical Physics through the HST MEMP program at Harvard and MIT. He joined Karp Lab in 2014 as a researcher and is currently building an in vitro biomimetic model of diabetes. Peter holds a Bachelor of Science in Plastics Engineering from the University of Massachusetts Lowell, a Bachelor of Arts in International Business Administration from the American University of Paris, and a Masters-level Certificate in Classical Vocal Performance from the Conservatoire Jean-Philippe Rameau in Paris, France. Peter has spent two years as a medical device engineer. Notably, he worked for six months as an intern on the orthopedics product development team at DePuy Mitek Sports Medicine (part of Johnson & Johnson). He also has five years of international experience in strategy consulting, sales and marketing. Peter is bilingual in French and conversant in Spanish. He enjoys hiking and nature and is an avid archer.

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Benjamin Elliott Mead

Hello, I’m a graduate student in the Harvard-MIT Medical Engineering and Medical Physics PhD program. My research interests revolve around regenerative medicine, specifically in the application of novel stem cell technologies towards the development of translational therapies. I received my bachelors degree in Chemical & Biological Engineering from the University of Colorado Boulder and have previously worked with the Harvard Stem Cell Institute and National Institute of Standards and Technology. In addition to research, I enjoy any and all outdoor activities (hiking, cycling, skiing, etc..) as well as photography and traveling.

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Kelvin Songyu Ng

Yes, Kelvin is my real name and my parents probably did intend for me to become a scientist obsessed about the thermodynamics of everything, even medicine, which, indeed, is the gist of Harvard-MIT Health Sciences and Technology, isn’t it? Here in the Karp Lab where opportunities abound, I hold dear to my training in biomaterials and drug delivery at the University of Wisconsin-Madison, so I’m only tinkering with cell therapy, medical devices, and molecular sensors. Naturally, my PhD thesis focuses on strategies for translating extracellular vesicles as a therapy. And because no man is an island, I partly work through collaborations with industry and other academic groups including the Wyss Institute. Counting my hyphens as I write, which many scientists should, I solve my perpetual problem of work-life(-sleep) balance mathematically by culinary exploration, badminton, table tennis, church, travel, socializing via LinkedIn, and navigating my mind palace the Sherlock Holmes way.

UNDERGRADUATES

Photo of Xueyin (Holly) He
Xueyin (Holly) He

Hi! My name is Xueyin (Holly) He. I’m an undergrad student from University of Toronto, and currently working as a research intern at Karp lab. My project focuses on developing a drug delivery platform using nanoparticles to treat multiple diseases, such as Dengue and Osteoarthritis. Our goal is to improve the clinical efficacy of drugs and at the same time reduce the side-effects by employing drug delivery systems. In my free time I’m passionate about reading, painting, and traveling. My plans for the future are to travel around the world to see different cultures and try all kinds of food!

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Heidi Xin Yi Kuang

Hello, my name is Heidi and I am an undergraduate student from the University of Toronto, specializing in Pharmacology and Biomedical Toxicology. At the Karp Lab, I am an intern in Dr. Oren Levy’s team. I am excited to work on projects that explore different bioengineering methods to enhance the therapeutic potential of human mesenchymal stem cells (MSCs) and MSC-derived exosomes. When I am not in the lab, I enjoy running along scenic routes, going to indie/alternative concerts, as well as following tennis and Chelsea FC.

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Thomas Mark Kuncewicz
I am a Research Assistant at the Karp Lab, and a Visiting Undergraduate Research Fellow in Don Ingber’s group at the Wyss Institute. Things that fascinate me include medical device design, Kanye West, tunable “smart” biomaterials, and the evolution of medical perspectives within new and unexplored areas of science.
My research is focused on the secretome of mesenchymal stem cells (MSCs) and other therapeutic cell types: one of our goals is to develop strategies which can facilitate large-scale production of cell-free, cGMP (stem cell-based) clinical products.
Photo of Hao Yue (Helena) Lan
Hao Yue (Helena) Lan

Hi! I’m a pharmacology student from University of Toronto, currently working as a research intern alongside Dr. Oren Levy. Our team focuses on exploring the properties of human mesenchymal stem cells (hMSCs), and aims to augment their therapeutic utility through a variety of bioengineering approaches. At the Karp Lab, I have the opportunity to collaborate with scientists with expertise in diverse fields, so I’m really looking forward to the innovative ideas we can come up with to improve the clinical outcome of hMSC-based therapies. Outside of the lab, I enjoy watching movies and dramas, as well as travelling – my goal is to explore all the touristic places in Boston and try as many good restaurants as I can during the time I’m here!

Photo of Dawn (Song Yi) Lin
Dawn (Song Yi) Lin

I’m a Mechanical Engineering student from University of Toronto. Currently, I’m assisting Dr. Yuhan Lee with his glue project. Being tired of long winters, Boston’s summer reignited my passion for outdoor jogging – you might spot me in Back Bay Fen some afternoons. I love all kinds of waterbodies, and the Charles River is absolutely a charm.

Photo of Siyu (Kalian) Shi
Siyu (Kalian) Shi

I am a research trainee from Rice University in Houston, Texas. My interests in future PhD work lie at the interface of neuroscience, regenerative medicine, and tissue engineering. Half of my bucket list is filled with restaurants to try and the other half with places around the world to visit. If not a physician-scientist, I would be a food chemist!

Photo of Liu Yi (Jamie) Wu
Liu Yi (Jamie) Wu

Hello, my name is Jamie and I am an undergraduate research intern from the University of Toronto, with a major in Biomedical Systems Engineering in the Engineering Science program. My project at Karp Lab focuses on creating an in vitro biomimetic model of diabetes for purposes such as disease modelling and drug screening. Research aside, I enjoy travelling and photography. I am fascinated by physics and astronomy in addition to being a cat enthusiast (Schrödinger’s and other types)!

Photo of De Hua (Andy) Yang
De Hua (Andy) Yang

Hello! My name is Andy and I am a student from University of Toronto, currently working as a research intern here at the Karp Lab. There are multiple research projects that I am involved in but the main objective is to employ stem cell-based strategies to treat major diseases such as diabetes and colitis. Outside of the lab, I enjoy going to different coffee shops and trying various drip coffee as well as lattes. In addition, I am a huge sports fan especially of my hometown teams (Let’s Go Raptors and Blue Jays!) and I personally play basketball and ultimate frisbee! This internship has been a great experience so far and I am loving the City of Boston, it is such a beautiful place!

Photo of Yixin (Sammy) Zheng
Yixin (Sammy) Zheng

ALUMNI