TEAM

 

JEFF KARP

Photo of Professor Jeffrey M Karp
Professor Jeffrey M Karp
Principal Investigator

Dr. Jeff Karp is an Associate Professor at Brigham and Women’s Hospital, Harvard Medical School, and is Principal Faculty at the Harvard Stem Cell Institute and affiliate faculty at MIT through the Harvard-MIT Division of Health Sciences and Technology. His research harnesses materials science and stem cell biology to solve medical problems with emphasis on nanoscale/microscale materials and bio-inspired approaches. He has published more than 100 peer-reviewed papers and book chapters and has given over 140 national and international invited lectures and has 50 issued or pending patents.

Several technologies that Dr. Karp has developed have formed the foundation for multiple products under development and for the launch of two companies, Gecko Biomedical and Skintifique.

Dr. Karp’s work has been recognized by CNN, NPR Science Fridays, Boston Globe, ABC News, MSNBC, Fox News, CBC Quirks and Quarks, CanadaAM, BBC, LA Times, Forbes, National Geographic, Popular Science, the Washington Post, the New York Post, and by Wired Magazine. In 2011 the Boston Business Journal recognized Dr. Karp as a Champion in Healthcare Innovation and in 2013 the Institute for Chemical Engineers (IChemE) awarded one of his technologies at the Most Innovative Product of the Year. MIT’s Technology Review Magazine (TR35) also recognized Dr. Karp as being one of the top innovators in the world under the age of 35. He has received the Society for Biomaterials Young Investigator Award and his work has been selected as one of Popular Mechanic’s “Top 20 New Biotech Breakthroughs that Will Change Medicine”. Dr. Karp was also elected in 2013 to the American Institute for Medical and Biological Engineering’s College of Fellows and as a Kavli Fellow.

Dr. Karp is also an acclaimed mentor. He was selected as the Outstanding Faculty Undergraduate Mentor among all Faculty at MIT and received the HST McMahon Mentoring award for being the top mentor among all faculty who mentor Harvard-MIT students. To date, 16 trainees from his laboratory have secured faculty positions at institutions throughout the world.

LAB MANAGER

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STAFF

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CO-MENTORED PERSONNEL

Photo of  Yi Dong Lin
Yi Dong Lin

Hi, I’m Yi-Dong Lin and I’m currently a postdoctoral fellow working under the supervision of Prof. Robert Langer at MIT and Prof. Jeffrey Karp at BWH. My current research project is developing and applying novel polymers for tissue engineering. I received my PhD degree in biomedical engineering in National Cheng Kung University in Taiwan in 2011, and then I had mt first postdoctoral training in Academia Sinica until February in 2014. My previous research topic is using biomaterial-based approach to enhance effcacy of drug and cell delivery for cardiovascular repair.

Photo of  Marc Succi
Marc Succi

I am a 4th year M.D. candidate at Harvard Medical School, currently conducting research in regenerative stem-cell therapeutics under Dr. Jeffrey Karp (BWH) and Dr. Robert Langer (MIT). My interests include clinically-oriented and translational cell-based therapeutics and tissue regeneration, as well as and diagnostic medical devices and telemedicine. My work in the lab currently focuses on expanding intestinal stem cells ex vivo using a novel scaffold system designed for implantation in intestinal disease. I received my Bachelors in Health Science from McMaster University in 2009 before moving to Boston for medical school. In addition to research and clinical device development, I love to play and watch hockey (go Montreal!) and develop useful web-based applications.

Photo of  Sufeng Zhang PhD
Sufeng Zhang PhD

Sufeng is currently an NSERC Postdoctoral Fellow at MIT. She is co-supervised by Professor Robert Langer and Jeffrey Karp. Her research areas include development of stem cell-based therapeutics and novel drug delivery systems for biomedical applications. She received her PhD degree in Chemical Engineering from the University of Alberta, where she worked with Professor Hasan Uludag. Her PhD research focused on delivering protein therapeutics to bone for bone regeneration, including chemical modification with bisphosphonates and physical encapsulation with nanoparticles.

CLINICAL INTERNS

Photo of  Nora Lang
Nora Lang

POST-DOCTORATES

Photo of  Woo Kyung Cho PhD
Woo Kyung Cho PhD

Hi!  I’m currently a postdoctoral associate in Prof. Karp’s lab at the Harvard-MIT division of Health Sciences and Technology, Harvard Medical School.  I joined in March, 2009.  My research topic is the design and fabrication of bio-inspired biomedical adhesives.  I received my Ph. D degree in organic chemistry in 2008 from KAIST in Korea.  During my Ph. D. course, I studied surface organic chemistry (self-assembled monolayers and design of bioactive surfaces), fabrication of functional surfaces (e.g. superhydrophobic surfaces and non-biofouling surfaces), formation of polymeric films on solid surfaces, and fabrication of nanostructures.  ACtually, most researches were related to bio-mimetic topics.  I think that learning from Nature gives us inspiration to develop artificial functional systems.

In addition to researches, I enjoy listening to music, playing tennis, watching movies and musicals, and traveling.

Photo of  Bryan Laulicht PhD
Bryan Laulicht PhD

Bryan is currently a postdoctoral associate in Professor Karp’s laboratory researching and developing bioinspired tape-based surgical adhesives. He received his PhD in medical science from Brown University (2010), where he was awarded the Joukowsky Family Foundation Outstanding Dissertation Award. While at Brown, he studied under Professors Edith Mathiowitz and Anubhav Tripathi investigating nanoencapsulation techniques, bioadhesives for oral drug delivery, pill force modeling, and magnetic pill retention.

Photo of  Yuhan Lee PhD
Yuhan Lee PhD

I’m a post-doctoral fellow in Karp Laboratory developing bio-adhesives for medical applications. I received my PhD in biological sciences in Korea Advanced Institute of Science and Technology (2010). While in KAIST, I studied under Professor Tae Gwan Park investigating biomaterials for wide variety of biomedical applications including drug/gene delivery and imaging for cancer therapy, injectable hydrogels for tissue regeneration, bio-inspired adhesive polymers for medical applications, carbon nanotube fiber fabrication, drug-eluting balloon catheter and stent for ischemic heart disease, and microneedle-based drug/gene delivery.

Photo of  Oren Levy PhD
Oren Levy PhD

I’m Oren Levy, a post doc in Prof. Karp’s lab. I received my B.Sc. in biology from Ben Gurion University (BGU), located in Beer Sheva, Israel. I carried out my M.Sc research in BGU, focusing on the JAK\STAT pathway and its involvement in vascular smooth muscle cell hypertrophy. During my PhD research, also performed in BGU, I studied the biochemistry and physiology of human mesenchymal stem cells (hMSCs). I investigated the roles of signal transduction pathways in hMSC physiological processes, specifically, the involvement of the JAK/STAT cascade in hMSC proliferation and osteogenic differentiation. My post doc research in the Karp lab focuses on hMSC homing and engraftment to various sites in the body. Hopefully, I will enjoy my work in the lab and have the privilege to engage in multiple collaborations with the great lab members.My hobbies include soccer, tennis and basketball. In addition, I’m a huge fan of F.C Hapoel BeerSheva (“Ani adom balev baneshama”).

Photo of  Oscar R Miranda PhD
Oscar R Miranda PhD

Oscar R. Miranda is a postdoctoral fellow in Prof. Karp lab at Brigham and Women’s Hospital, Harvard Medical School and Harvard-MIT Division of Health Sciences and Technology (HST), his work is focused on developing the next generation of drug delivery systems, stem cells based systems and biomaterials for therapeutics applications in biomedicine. In 2010, He obtained his Ph.D. degree in Prof. Vincent M. Rotello’s lab at the University of Massachusetts at Amherst, where his dissertation was focused on engineering nanoparticles surface for biosensing and other biological applications. He was very privileged to be awarded the William E. McEwen outstanding graduate student award during his stint at UMass-Amherst. In 2005, He obtained a MSc degree in Prof. Temer S. Ahmadi lab at Villanova University in Pennsylvania. He research was focused in the effects of intensity and energy of CW-UV light on the nucleation and growth of gold nanorods (AuNRs), where he won the 1st place in Villanova University chapter of SIGMA XI, research day. He obtained his BE in Chemical Engineering from National University of Engineering (UNI) and a postgraduate (MBA) in Marketing from Central American University (UCA) in Nicaragua.

In addition to researches, He enjoys listening to music, watching movies and sports, dancing, traveling, ping pong, tennis, jogging, boxing, martial art, gym, out/in door activities. He eats everything so he likes go to all international restaurants and taste everything including beers!

Photo of  Eoin O’Cearbhaill PhD
Eoin O’Cearbhaill PhD

Hi. I joined the Karp Lab in March 2011 as a postdoctoral fellow. My work focuses on developing novel needle based medical devices. I obtained my BE (Biomedical) in 2003 and PhD in 2007 from the National University of Ireland, Galway. My doctorate focused on applying mechanical stimulation to MSCs for vascular tissue engineering applications, under the supervision of Prof. Peter McHugh. Since then, I have worked in industry and academia, in both Ireland and Boston, designing and manufacturing medical devices. When I’m not in the lab, I enjoy playing gaelic (Irish) football, soccer, skiing, travelling the world and brewing beer and cider (with mixed results).

Photo of  Mohammad Qasaimeh
Mohammad Qasaimeh

Mohammad Qasaimeh joined the Karp’s (Harvard Medical School) and Karnik’s (Massachusetts Institute of Technology) laboratories in September 2013 as a Postdoctoral Associate, and will be joining New York University, Abu Dhabi in August 2014 as an assistant professor of Mechanical and Biomedical Engineering. Mohammad received his B.S. in Mechanical/Mechatronics Engineering from Jordan University of Science and Technology, a M.A.Sc in Mechanical Engineering from Concordia University, Montreal, Canada and a PhD in Biomedical Engineering from McGill University, Montreal, Canada, in 2006, 2008 and 2013, respectively. Mohammad has been the recipient of several prestigious fellowships and awards including the NSERC Postdoctoral Fellowship, the Alexander Graham Bell Graduate Scholarship (CGSD3), the Students-Researchers Stars Award from the Fonds de recherche du Quebec (FQRNT), the BME Excellence Award from McGill University, and several best poster awards in institutional and international conferences. His current research interests include developing novel microfluidic devices for the study of cellular dynamics and for point of care diagnostics, and developing MEMS devices for biomedical application.

Photo of  Praveen Kumar Vemula PhD
Praveen Kumar Vemula PhD

Currently, I am a Postdoctoral Research Associate in Dr. Jeffrey Karp’s laboratory (the laboratory for Advanced Biomaterials and Stem-Cell-based Therapeutics) at Harvard-MIT division of Health Science and Technology, Harvard Medical School. I received Ph.D. degree from the Department of Organic Chemistry, Indian Institute of Science, Bangalore, India in 2005 (supervisor: Prof. Santanu Bhattacharya). During graduation I carried out my research in the area of developing novel catalysts for decontamination reactions in supramolecular aggregates. After receiving my degree I have joined as postdoctoral fellow in Dr. George John’s laboratory at the City College of New York, where extensively I worked on developing various biobased amphiphiles to generate soft nanomaterials such as molecular hydro/organo gels, liquid crystals, self-assembled organic nanoarchitectures and their utilization in synthesizing various metal nanoparticles using novel in-situ methods.

Currently my research interest includes designing advanced bionanomaterials for generating novel stem-cell-based therapeutics for regenerative medicine.

My hobbies include playing badminton (I just love that game!), running, reading novels, watching movies and visiting friends etc (hmmm… I need more hours per day!!!)

Photo of  Nikken Wiradharma PhD
Nikken Wiradharma PhD

Hello! I’m Nikken, and I join Prof. Karp’s lab since June 2012. In Karp’s lab I will be developing biosensor technologies to gain a better understanding of in vivo biological phenomena. I received my PhD in Chemical and Biomolecular Engineering from the National University of Singapore (NUS) in 2010. My dissertation in NUS was focused on studying the self-assembly of peptide nanostructures for anticancer drug and gene delivery, under a joint supervision from Prof. Yen Wah TONG (NUS), and Dr. Yi-Yan YANG (IBN, A*Star). Subsequently, I joined Dr. Yang’s lab at IBN for my first postdoc appointment to develop various peptide and polymeric biomaterials for macromolecular therapies against infectious diseases. Now I look forward to working with great teammates at Karp Lab. Other than having fun in the lab, I also enjoy outdoor activities, travelling and eating; and my favorite past-time is listening to music, watching movies, simple exercises like jogging, swimming, or gym exercise, and enjoying pints of “HiNikken” with friends…

Photo of  Seung Yun Yang PhD
Seung Yun Yang PhD

Hi! I joined Karp group in September, 2010 as a postdoctoral associate. My current research interests are development of biomedical adhesive and drug delivery by using self-assembled materials. I obtained my Ph.D. degree in Prof. Jin Kon Kim’s group in 2010 from POSTECH in Korea, where I focused on the nanoporous materials based on block copolymer self-assembly for biomedical applications such as virus filtration and protein or gene drug delivery. And I studied metal oxide nanotubular structure prepared from polymer template for optical and sensor applications. My personal interests are playing sports, especially kumdo, and travelling.

Photo of  Zijiang Yang PhD
Zijiang Yang PhD

Hi, I joined Prof. Karp’s lab since Feb. 2011 as a research fellow sponsored by Swiss National Science Foundation. I obtained my PhD degree from University of Bern, Switzerland in 2010 and before that, my MSc degree from Uppsala University/Karolinska Institute in Sweden, 2007. My research interests are adult stem cell based regenerative therapies, especially on the improvement of their efficiency and feasibility by utilizing novel biomaterial and cutting-edge biotechnology. I am so excited to join this talented family.

GRADUATES

Photo of  Allison Hamilos
Allison Hamilos

Allison is an adventurous medical student in the Harvard-MIT Division of Health Sciences and Technology who loves exploring new places, playing lacrosse, laughing rambunctiously, and making new friends. Her passions include singing with the HMS Heartbeats a capella group, her Saturday morning radio show, teaching, mentoring, and trying unusual foods. She is a graduate of MIT and holds Sc.B degrees in biology and chemistry. As an undergrad, she had the pleasure of working with Dr. Catherine Drennan to elucidate the crystal structure of ribonucleotide reductase with its allosteric inhibitor and Dr. Monty Krieger to investigate the mechanism of oocyte death in mice with impaired cholesterol homeostasis. She has also collaborated with the Rigotti Laboratory in Santiago, Chile investigating murine infertility. Allison is thrilled to join the Karp Lab in its pursuit of creative solutions to medical problems. She and her teammates are currently designing devices for treating Type I diabetes.

Photo of  Benjamin Elliott Mead
Benjamin Elliott Mead

Hello, I’m a graduate student in the Harvard-MIT Medical Engineering and Medical Physics PhD program. My research interests revolve around regenerative medicine, specifically in the application of novel stem cell technologies towards the development of translational therapies. I received my bachelors degree in Chemical & Biological Engineering from the University of Colorado Boulder and have previously worked with the Harvard Stem Cell Institute and National Institute of Standards and Technology. In addition to research, I enjoy any and all outdoor activities (hiking, cycling, skiing, etc..) as well as photography and traveling.

Photo of  Kelvin Songyu Ng
Kelvin Songyu Ng

Hi! I am currently pursuing a PhD in Medical Engineering & Medical Physics with the Harvard-MIT Division of Health Sciences & Technology. I graduated from the University of Wisconsin-Madison with a bachelor’s degree in biomedical engineering, and there I developed an interest for drug delivery and cell/tissue engineering strategies that can be rapidly translated into the clinic. I joined the Karp Lab in Fall 2010; my focus is to develop technologies to advance stem cell therapy into the clinic. Research aside, I am an avid foodie who enjoys badminton, movies, and music.

Photo of  Joon Faii Ong
Joon Faii Ong

Hey there! I’m a medical student at Imperial College London. In my second year here I’m developing PLGA microcarriers carrying conventional immunosuppressants and coated with mesenchymal stem cells, for local subcutaneous delivery in hand and face transplants. I am also assisting with two other projects. I am grateful for the supportive, fun and dynamic environment here at the Karp lab, and am most certainly looking forward to making the best of my time here.

I intend for my experiences here to augment my surgical aspirations with a proper grounding in regenerative medicine and biomedical engineering.

In my spare time, I fence, tinker with audio electronics, sing, cook, work out, read Buddhist philosophy and dabble in humanitarian work

Photo of  Maria N Pereira
Maria N Pereira

Hi everyone! My name is Maria and I´m from Portugal. I did my undergrad and master degrees in Pharmaceutical Sciences at the University of Coimbra. Currently, I’m a graduate student at the MIT-Portugal Program now enjoying the opportunity of developing my research in collaboration with Prof. Jeff Karp’s lab. I’m working on the field of biomaterials and nanotechnologies, more specifically on the gecko adhesive project. My major objective is to create new materials that can be rapidly translated into the clinic to help others! Besides that I love travelling (a lot!), watching films and eating good food.

Photo of  Grace Sock Leng Teo
Grace Sock Leng Teo

I joined the Karp Lab in 2008 for a 7-month internship during my undergraduate studies at Nanyang Technological University in Singapore, and found the research here stimulating. Hence, I returned to complete my PhD studies here, and am currently enrolled in the Harvard-MIT Division of Health Sciences and Technology program (Medical Engineering Medical Physics track). My research covers mesenchymal stem cell biology and therapeutics, and I am also interested in technology for third world applications, and raising standards of education in SE Asia.

UNDERGRADUATES

Photo of  Priya Anandakumaran
Priya Anandakumaran

I am an intern from the University of Toronto, where I’m in the Engineering Science program with a major in biomedical engineering. At the Karp Lab I will be working with Dr. Oren Levy on a number of projects regarding mesenchymal stem cells, specifically related to cell homing. My prior research experience focused on developing an in vitro model for staining the cornea with fluorescein to determine the effects of fluorescein at the cellular level, so I am very excited to learn more about regenerative medicine and other aspects of biomedical engineering during my time here. Outside of the lab I enjoy reading, watching (many) tv shows, playing the clarinet and exploring Boston.

Photo of  Caroline Chen
Caroline Chen

I am an undergraduate at Tufts University, majoring in Cognitive and Brain Sciences. During my internship, I will be working with Grace Teo researching the mechanism of mesenchymal stem cell transmigration across the endothelium, as well as with Kelvin Ng focusing on developing research tools to study mesenchymal stem cells in vivo. My previous research experiences involved studying stem cells and cancer biology, and developing a new way to radio-protect hematopoietic cells so I am very excited to learn more about stem cell biology and therapeutics. Outside of the lab, I enjoy exploring Boston, cooking, and writing.

Photo of  Riddhi G Dastidar
Riddhi G Dastidar

I’m an intern from the University of Waterloo, where I’m in the Life Sciences program with a major in Molecular Genetics and a minor in Psychology. At the Karp lab, I work with James on developing a novel method to augment mesenchymal stem cell therapy for inflammation using drug loaded microparticles that have been engineered at the lab. We hope that our research will have wide ranging applications in treating diseases like Graft vs host disease and Crohn’s disease.
Following my internship here, I will be working at the lab of Dr. Matthijs van der  Meer  for my senior thesis, and pursuing  research in the mechanisms that underlie learning, memory and decision making. In the future I hope to go on to do my PhD. In Neuroscience and pursue research in neurodegenerative disorders.

Outside of the lab I can usually be found at a café or a park bench, writing my version of the great American novel and drinking entirely too much coffee. My list of obsessions include literature, poetry (Bukowski is a favourite), music, photography, food, child rights, cats, and travelling. Some of my favourite parts of the city would be the Holocaust Memorial on the Freedom Trail, the River Gods pub in Cambridge and The Paramount diner by Beacon Hill.

Photo of  Sarah Fischer
Sarah Fischer

Hi! I’m Sarah, a german exchange student from Saarland University. I will be spending my Masters in materials science here at the KarpLab. I am a member of the Functional Surfaces research group of the Leibniz Institute for New Materials in Germany, directed by Prof. Eduard Arzt, and my project will be both supervised by KarpLab and INM members. My fields of interest include the development and testing of new and versatile adhesive structures for medical applications with a special emphasis on wet adhesion and bioinspiration. I am really looking forward to join such a multidisciplinary laboratory.

In my free time I practice ballroom dancing, enjoy reading, baking and discovering new cities by foot armed with a photo camera.

Photo of  Nathan Holwell
Nathan Holwell

I am an intern from the University of Waterloo studying in the Nanotechnology Engineering program. I will be under the supervision of Dr. Yuhan Lee, working on novel applications of a new polymer and its derivatives. I will also be assisting Kelvin and Allison as they develop a new technology as a solution to type I diabetes.

I am excited to be a part of the Karp Lab, as I strongly reinforce the mission of translating technologies from the lab bench to the bedside.

Outside the lab, I am hoping to explore more of Boston by exploring its diverse food, history and sights.

Photo of  Christian Landeros
Christian Landeros

I am an undergraduate in my third year at Massachusetts Institute of Technology studying Biological Engineering. At the Karp Lab, I will be working with Dr. Nikken Wiradharma in developing biosensor technologies for use in cancer diagnostics, particularly working with microfluidic devices. Past research has focused mainly in tissue engineering, and I am excited to be working in a lab with more medically oriented goals. If not in lab or working on problem sets, I like going home to New York, exploring Boston, going to concerts, and listening to music.

Photo of  Jessica Ngai
Jessica Ngai

I am currently an intern from the University of Toronto’s Engineering Science program, with a major in Biomedical Engineering. During my internship, I will be working under the mentorship of Dr. Oren Levy on various mesenchymal stem cells (MSC) projects, mainly focusing on the cell homing project.

I’m excited about working more on the biological side of biomedical engineering, compared to my previous internships that were electrical and computer engineering based, and especially at such a prestiguous and multi-disciplinary lab. Aside from lab work, I enjoy travelling, checking out local eateries, listening to music and playing sports.

Photo of  Shrey Sindhwani
Shrey Sindhwani

I spent the first 18 years of my life in New Delhi (India). During high school, my interest in the magical world of nanotechnology peaked. With my family’s Canadian immigration, everything aligned and I enrolled into the B.A.Sc. Nanotechnology Engineering program at University of Waterloo. I absolutely loved my time at Waterloo and graduated from this program in 2011. At Karp Lab, I am conducting research at the interface of nanotechnology and medicine. Specifically, I am developing novel drug delivery technologies towards the goal of making them more adhesive. My second project deals with stem cell engineering and biosensors for studying physiological changes in the cellular environment.

Outside the lab, I am an avid soccer ( the real football) fan and enjoy playing it both indoors and outdoors. My favourite teams are Arsenal and Barcelona. I also play squash to let off the steam! I listen to rock and alternative music ( The Black Keys, Cage The Elephant, Arkells, Arcade Fire, Nirvana, U2…..) and some Indian music.

Photo of  Lawrence Yu
Lawrence Yu

I am an intern from University of Waterloo’s Nanotechnology Engineering program.

I will be working with Eoin O’Cearbhaill on a number of projects related to microfluidic and needle devices.

In my spare time, I enjoy ultimate frisbee, music, and good food.

 

Comentored Personnel

xiaolei small Xiaolei Yin, PhD sudhirsmall Sudhir H. Ranganath, PhD

shrey Shrey Sindhwani Ben 1 Ben Ouyang
Lara Lara Fu fangqi Fangqi Gu
SBoettoPic Sarah Boetto Hongmin Hongmin Chen 
michaelvalic Michael Valic 193600 1614073445910 1658520274 2405112 6034327 o Kyle Tsang

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