h.marcal

August 26, 2007

Collaborators

Jeff Borenstein – Director of the Biomedical Engineering Center, Draper Laboratory (nanofabrication)

 

Christopher V. Carman – Assistant professor, Beth Israel Deaconess (Molecular & Vascular Medicine)

 

David Carter – Draper Laboratory (nano/microfabrication)

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August 26, 2007

Biomaterials

SELF-ASSEMBLING DRUGS

One of the fundamental problems in drug-delivery is striking a balance between toxicity and therapeutic effect. Hydrogels have been widely applied as intelligent carriers in controlled drug-delivery systems. Self-assembled hydrogel-based drug-delivery has been hindered by the unknown fate of the host gelator after the gel degradation. Thus, we propose a conceptually novel approach to address these limitations. The existing ambiguity can be substantially decreased by designing prodrug-based LMWGs from existing drugs whose metabolic pathways are well documented (See Figure below).

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August 26, 2007

Medical Devices

NEEDLES THAT SENSE TRAVEL THROUGH TISSUES
In collaboration with Alex Slocum and Erik Bassett at MIT, we have developed a new needle sensing device that can detect travel of needles through various tissues. This can be used to significantly reduce complications associated with placement of needles, wires and catheters.

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August 26, 2007

Stem Cell Engineering

INTRAOPERATIVE STEM CELL THERAPY

We are working towards development of intraoperative autologous stem cell based therapeutics that can be performed rapidly under emergent situations (e.g., within emergency room or battlefield settings).

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